Evolution. Natural selection and pain meet at a sodium channel.
نویسنده
چکیده
NEWS & ANALYSIS 409 Ancient DNA Links Native Americans With Europe >> Science Podcast 410 U.S. Shutdown Ends, but Not Budget Anxiety 411 Earliest Known Galaxy Formed Stars at a Breakneck Pace 412 U.K. Science Adviser Faces Emotionally Charged Issues and Uncertain Science 413 Immune Suppressant Unexpectedly Boosts Flu Vaccine 415 Surprising New Dengue Virus Throws a Spanner in Disease Control Efforts
منابع مشابه
Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.
Approximately 75% of vertebrate proteins belong to protein families encoded by multiple evolutionarily related genes, a pattern that emerged as a result of gene and genome duplications over the course of vertebrate evolution. In families of genes with similar or related functions, adaptation to a strong selective agent should involve multiple adaptive changes across the entire gene family. Howe...
متن کاملConstraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.
Natural selection often produces convergent changes in unrelated lineages, but the degree to which such adaptations occur via predictable genetic paths is unknown. If only a limited subset of possible mutations is fixed in independent lineages, then it is clear that constraint in the production or function of molecular variants is an important determinant of adaptation. We demonstrate remarkabl...
متن کاملTemperature-dependent model of human cardiac sodium channel
Cardiac sodium channels are integral membrane proteins whose structure is not known at atomic level yet and their molecular kinetics is still being studied through mathematical modeling. This study has focused on adapting an existing model of cardiac Na channel to analyze molecular kinetics of channels at 9-37°C. Irvine et al developed a Markov model for Na channel using Neuronal Network Model ...
متن کاملSodium channel genes and the evolution of diversity in communication signals of electric fishes: convergent molecular evolution.
We investigated whether the evolution of electric organs and electric signal diversity in two independently evolved lineages of electric fishes was accompanied by convergent changes on the molecular level. We found that a sodium channel gene (Na(v)1.4a) that is expressed in muscle in nonelectric fishes has lost its expression in muscle and is expressed instead in the evolutionarily novel electr...
متن کاملEffect of Equal Channel Angular Pressing and Annealing Treatment on the Evolution of Microstructure in AlMg0.7Si Aluminum Alloy
In this research, samples of AlMg0.7Si aluminum alloy are deformed up to three passes using equal channel angular pressing (ECAP). Formation of a sub-micron structure after three passes of ECAP is demonstrated. Microstructural stability of the samples is investigated at temperatures of 300-500 °C. At 300 °C, fine recrystallized structure forms after 10 min which remains stable when the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Science
دوره 342 6157 شماره
صفحات -
تاریخ انتشار 2013